Consistent with USP and EP.
Properties: powder, water solubility: 50mg/mL
White or almost white powder. Almost odourless. Sensitive to light. Hygroscopic. Soluble in water, slightly soluble in ethanol.
Uses: gram negative bacteria, polypeptide antibiotics, can change the membrane structure, so that leakage of small molecules, and inhibit the growth of gram negative bacteria. Bactericidal action against Escherichia coli. The lipid A fraction bound to bacterial lipopolysaccharides. Small holes are induced in the outer membrane of the skin.
Mode of action: binding and interfering permeability of cell plasma membrane. Antimicrobial spectrum: gram negative bacteria.
Bacitracin zinc is a polypeptide antibiotic, which has bactericidal effect on Gram-positive bacteria. Its mechanism is mainly to inhibit the synthesis of bacterial wall, and can also combine with the cell membrane of sensitive bacteria, damage the integrity of cell membrane and lead to the outflow of important substances in cells. Effectively inhibit Gram-positive bacteria and some Gram-negative bacteria;
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PTBT, 4-Tert-butyl toluene